SpectralBio

Artifact role: research reproducibility artifact

Flagship scientific result: BRCA2 covariance-aware augmentation against a stronger ESM-1v ensemble

Validation anchor: TP53 frozen public canonical replay surface

Primary benchmark: TP53 canonical executable benchmark

Secondary benchmark: bounded transfer on a fixed BRCA1 subset (N=100)

Transfer framing: secondary transfer evaluation without retraining

Adaptation note: adaptation recipe only

This Space renders shared-core executable outputs only. BRCA2 scientific centrality lives in the paper-aligned audit surfaces, while TP53 remains the default workflow here.

Preset-first workflow

TP53 presets stay first because the executable contract is TP53-first. BRCA1 presets remain clearly secondary bounded transfer examples, while BRCA2 remains the manuscript-facing flagship scientific result.